Corona virus wreaks havoc in India, experts say

The second wave of corona virus has wreaked havoc in India, with more than 300,000 new cases being reported daily and thousands dying. Recently, experts have made a new revelation in this regard.

According to the international website, the multi-laboratory network (INSACOG) was set up at the government level after the discovery of the Brona virus type B117 in India.

On March 24, the network announced the discovery of a double mutant type.

By the way, this kind of announcement was made in March 2021, but it was discovered in the symbolic database of code sequencing in October 2020, but not much attention was paid at that time. This new strain is likely to spread more rapidly and is the result of more than 60% of cases in the Indian state of Maharashtra alone.

The emergence of more rapidly spreading species points to a limited global surveillance system that is not working in remote areas.

The INSACOG was expected to produce genetic sequences of 5% of all positive cases in all states, but by April 15, only 13,000 sequences could be produced.

What is a double mutant?

Viruses often change and are not specific but mutate in places.

New corona viruses, HIV and influenza viruses all use molecular RNA for genetic instruction and change more frequently than other viruses, causing the virus to replicate in host cells. There are mistakes.

The global public database contains millions of genetic sequences of the new corona virus, many of which have gone unnoticed, but some mutations have altered the amino acids that underlie the development of viral protection, resulting in their Features changed.

When one or more mutations persist, a new type is formed that is different from the other types and is given a new name. The new species discovered in India has been named B1617 which has 2 mutations. The first mutation occurred in spike protein 452 and the second in protein 484.

By the way, this new type has not only undergone 2 mutations but a total of 13 mutations, of which 7 are present in the spike protein.

The virus uses spike proteins to bind to S2 receptor proteins on the surface of the lungs and other human cells and then makes them sick. The 8th mutation in the virus occurred in the middle of an immature spike protein that could accelerate the spread of the virus.

According to experts, research on mutations in the Indian type has been done separately but not collectively. The important thing is that a lot has changed in its spike protein.

It is not the number of mutations but their location that matters

According to experts, this is often the case in viruses. Surface proteins undergo rapid evolutionary stages, especially in a new virus, so that they can bind to cells in a much better way.

Because the spike protein is present at the surface of the new corona virus and is the primary target of the immune system, immune cells produce antibodies that can detect and inactivate the virus.

That’s why the currently available code vaccine uses spike protein to train the body to prevent disease.

Changes in the spike protein alter its shape and structure, which helps the virus fight off antibodies, increasing the virus’s ability to survive and replicate.

According to experts, any mutation in the spike protein affects the function, spread and other effects of the virus.

Various research reports suggest that a mutation called L452R increases the virus’s ability to infect cells, meaning that it rapidly replicates itself and binds more strongly to the S2 receptor.

Similarly, a mutation called E484 helps prevent the virus from inactivating antibodies.

Type M1617, discovered in India, contains both of these mutations and could therefore be a potentially very difficult type, requiring more research.

Spread globally

B1618 has reached different countries of the world very fast and so far it has been discovered in 1 country.

As it has undergone a lot of mutations, this may be one of the reasons for the rapid rise of the epidemic in India at the moment, but it is difficult to say definitively at this time.

Some preliminary evidence suggests that existing vaccines are effective against this new type, while precautions such as face masks, social distance and frequent hand washing are also very effective in preventing it.

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